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PMID: 29985865 [Pub Med - indexed for MEDLINE] Related Articles Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by Hox B13. 2018 06 26;115(26):6810-6815 Authors: Chen Z, Wu D, Thomas-Ahner JM, Lu C, Zhao P, Zhang Q, Geraghty C, Yan PS, Hankey W, Sunkel B, Cheng X, Antonarakis ES, Wang QE, Liu Z, Huang TH, Jin VX, Clinton SK, Luo J, Huang J, Wang Q Abstract The constitutively active androgen receptor (AR) splice variant 7 (AR-V7) plays an important role in the progression of castration-resistant prostate cancer (CRPC).Although biomarker studies established the role of AR-V7 in resistance to AR-targeting therapies, how AR-V7 mediates genomic functions in CRPC remains largely unknown.Related Articles The mechanical and hemodynamic effects of left ventricular pacing in heart failure with preserved ejection fraction and left bundle branch block. 2018 Sep - Oct;51(5):859-862 Authors: Friedman DJ, Emerek K, Søgaard P, Vejdani-Jahromi M, Kisslo J, Atwater BD Abstract Cardiac resynchronization therapy (CRT) has revolutionized the care of patients with heart failure with reduced ejection fraction (HFr EF) and left bundle branch block (LBBB); some hypothesize that electrical resynchronization may also benefit patients with heart failure with preserved ejection fraction (HFp EF) and LBBB.We assessed the acute hemodynamic and mechanical impact of temporary LV pacing in 2 patients with HFp EF and LBBB and a "classic" pattern of echocardiographic dyssynchrony.Surprisingly, we discover that Hox B13 is universally required for and colocalizes with AR-V7 binding to open chromatin across CRPC genomes.Hox B13 pioneers AR-V7 binding through direct physical interaction, and collaborates with AR-V7 to up-regulate target oncogenes.MATERIALS AND METHODS: A systematic review of Pub Med, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Excerpta Medica database (EMBASE), and Web of Science identified all surgically treated penile and scrotal melanomas that reported local recurrence status and follow-up time.
PMID: 29844167 [Pub Med - indexed for MEDLINE] Related Articles Habitat degradation negatively affects auditory settlement behavior of coral reef fishes. 2018 05 15;115(20):5193-5198 Authors: Gordon TAC, Harding HR, Wong KE, Merchant ND, Meekan MG, Mc Cormick MI, Radford AN, Simpson SD Abstract Coral reefs are increasingly degraded by climate-induced bleaching and storm damage.
Metabolomic analysis upon fatty acid supplementation revealed a β-oxidation fueled ATP elevation that coincided with presence of junctional complexes, intercalated discs, t-tubule-like structures and adult isoform of cardiac troponin T.